{"id":134951,"date":"2023-05-02T12:25:00","date_gmt":"2023-05-02T10:25:00","guid":{"rendered":"https:\/\/eurecat.org\/?post_type=avada_portfolio&#038;p=134951"},"modified":"2023-11-29T12:59:37","modified_gmt":"2023-11-29T11:59:37","slug":"opade","status":"publish","type":"avada_portfolio","link":"https:\/\/eurecat.org\/en\/portfolio-items\/opade\/","title":{"rendered":"OPADE"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-overflow:visible;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_2_3 2_3 fusion-two-third fusion-column-first\" style=\"--awb-bg-size:cover;width:65.3333%; margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\" style=\"--awb-text-transform:none;\"><p><img decoding=\"async\" class=\"alignnone size-full wp-image-134956\" src=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447.jpg\" alt=\"OPADE EURECAT\" width=\"850\" height=\"447\" srcset=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447-200x105.jpg 200w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447-300x158.jpg 300w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447-400x210.jpg 400w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447-600x316.jpg 600w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447-768x404.jpg 768w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447-800x421.jpg 800w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/OPADE_850x447.jpg 850w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-title title fusion-title-1 fusion-title-text fusion-title-size-three\" style=\"--awb-margin-top-small:0px;--awb-margin-right-small:0px;--awb-margin-bottom-small:20px;--awb-margin-left-small:0px;\"><h3 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\"><\/h3><span class=\"awb-title-spacer\"><\/span><div class=\"title-sep-container\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#e0dede;\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\" style=\"--awb-text-transform:none;\"><p><strong>Identification of key biomarkers in major depressive disorder to support the decision-making process of healthcare professionals.<\/strong><\/p>\n<p>The <strong>OPADE<\/strong> project focuses on the <strong>microbiota-brain axis<\/strong>, which plays a major role in mental health and, in particular, in <strong>major depressive disorders (MDD)<\/strong>.<\/p>\n<p>OPADE studies the combination between genetics, epigenetics, metabolism, immune system, microbiome and inflammatory networks to:<\/p>\n<ul>\n<li>Establish patient profiles to <strong>predict and optimise the efficacy of the antidepressants<\/strong> prescribed with an increase in the remission rate.<\/li>\n<li>Establish the possible <strong>correlation between inflammatory markers, metabolomics, epigenomics, genomics, immune profile and microbiome with mental disorders<\/strong>.<\/li>\n<li>Evaluate<strong> molecular and non-molecular biomarkers<\/strong> that may represent predictive indices of recurrence.<\/li>\n<li>Discover new molecular targets for a <strong>personalised approach<\/strong>.<\/li>\n<li>Improve the <strong>diagnostic accuracy<\/strong> for primary prevention.<\/li>\n<\/ul>\n<p>The main outcome of the project is an <strong>Artificial Intelligence\/Machine Learning predictive tool<\/strong>, which is trained from the cognitive assessment and biochemical parameters, that can predict the efficacy of anti-depressant and personalises the treatment.<\/p>\n<p>Moreover, a <strong>patient empowerment tool<\/strong> is being deployed including a chat room to capture patients\u2019 stories and give advice to improve their quality of life.<\/p>\n<p>Worldwide, <strong>more than 280 million people suffer from MDD<\/strong>. Although the therapeutic landscape of anti-depressants is well-designed, 50% of patients are not properly diagnosed, 75% are not treated and, from those under medication, the number of patients in remission is particularly low with not more than 6% who benefit from an accurate treatment.<\/p>\n<p>Under this terrible situation, the research for personalised medicine, from diagnostic to treatment, is a key aspect of mental healthcare.<\/p>\n<p>The <a href=\"https:\/\/eurecat.org\/en\/field-of-knowledge\/omic-sciences\/\">Omic Sciences Unit<\/a> from Eurecat is involved in the analysis of different biochemical parameters in blood to search for predictive biomarkers for personalised medicine and increased accuracy of the anti-depressant treatment.<\/p>\n<p>The OPADE project, led by the <a href=\"https:\/\/www.ebris.eu\/\" target=\"_blank\" rel=\"noopener\">European Biomedical Research Institute of Salerno<\/a>, is made up of <strong>14 organisations from 10 different countries<\/strong>.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_3 1_3 fusion-one-third fusion-column-last\" style=\"--awb-bg-size:cover;width:30.6666%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"210\" alt=\"LOGO OPADE EURECAT\" title=\"Logo OPADE\" src=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/Logo-OPADE-400x210.png\" class=\"img-responsive wp-image-134959\" srcset=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/Logo-OPADE-200x105.png 200w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/Logo-OPADE-400x210.png 400w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/Logo-OPADE-600x315.png 600w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/Logo-OPADE-800x420.png 800w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/Logo-OPADE-1200x630.png 1200w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/05\/Logo-OPADE.png 1299w\" sizes=\"(max-width: 800px) 100vw, 600px\" \/><\/span><\/div><\/div><div class=\"fusion-title title fusion-title-2 fusion-title-text fusion-title-size-three\" style=\"--awb-margin-top-small:0px;--awb-margin-right-small:0px;--awb-margin-bottom-small:20px;--awb-margin-left-small:0px;\"><h3 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">General details<\/h3><span class=\"awb-title-spacer\"><\/span><div class=\"title-sep-container\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#e0dede;\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-3\" style=\"--awb-text-transform:none;\"><p><strong>Project<\/strong><\/p>\n<p>OPADE \u2013 Optimise and Predict Antidepressant efficacy for\u00a0patients suffering from major DEpressive disorders using multi-omics analysis and AI-predictive tool<\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-4\" style=\"--awb-text-transform:none;\"><p><strong>Project reference<\/strong><\/p>\n<div class=\"fusion-text fusion-text-4\">\n<p>101095436<\/p>\n<\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-5\" style=\"--awb-text-transform:none;\"><p><strong>Programme and call for tender<\/strong><\/p>\n<p>Project funded by the European Union\u2019s Horizon Europe programme under the call <em>HORIZON-HLTH-2022-TOOL-11\u2013 Tools and technologies for a healthy society<\/em><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-6\" style=\"--awb-text-transform:none;\"><p><strong>Project website<\/strong><\/p>\n<div class=\"fusion-text fusion-text-6\">\n<p><a href=\"https:\/\/opade-project.eu\/\" target=\"_blank\" rel=\"noopener\">www.opade-project.eu<\/a><\/p>\n<\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"84\" src=\"https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-400x84.jpg\" alt class=\"img-responsive wp-image-143603\" srcset=\"https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-200x42.jpg 200w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-400x84.jpg 400w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-600x126.jpg 600w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-800x168.jpg 800w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-1200x252.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 600px\" \/><\/span><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":33,"featured_media":134962,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"portfolio_category":[1413,1522],"portfolio_skills":[2483],"portfolio_tags":[],"class_list":["post-134951","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-european-projects","portfolio_category-omic-sciences","portfolio_skills-horizon-europe-3"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>OPADE - Eurecat<\/title>\n<meta name=\"description\" content=\"OPADE \u2013 Optimise and Predict Antidepressant efficacy for patients suffering from major DEpressive disorders using multi-omics analysis and AI-predictive tool\" \/>\n<meta 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