{"id":142864,"date":"2023-11-09T17:32:46","date_gmt":"2023-11-09T16:32:46","guid":{"rendered":"https:\/\/eurecat.org\/?post_type=avada_portfolio&#038;p=142864"},"modified":"2023-12-01T09:46:21","modified_gmt":"2023-12-01T08:46:21","slug":"pas-gras","status":"publish","type":"avada_portfolio","link":"https:\/\/eurecat.org\/en\/portfolio-items\/pas-gras\/","title":{"rendered":"PAS-GRAS"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-overflow:visible;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_2_3 2_3 fusion-two-third fusion-column-first\" style=\"--awb-bg-size:cover;width:65.3333%; margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\" style=\"--awb-text-transform:none;\"><p><img decoding=\"async\" class=\"alignnone size-full wp-image-142869\" src=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447.jpg\" alt=\"PAS-GRAS EURECAT\" width=\"850\" height=\"447\" srcset=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447-200x105.jpg 200w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447-300x158.jpg 300w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447-400x210.jpg 400w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447-600x316.jpg 600w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447-768x404.jpg 768w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447-800x421.jpg 800w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/PAS-GRAS_850x447.jpg 850w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-title title fusion-title-1 fusion-title-text fusion-title-size-three\" style=\"--awb-margin-top-small:0px;--awb-margin-right-small:0px;--awb-margin-bottom-small:20px;--awb-margin-left-small:0px;\"><h3 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\"><\/h3><span class=\"awb-title-spacer\"><\/span><div class=\"title-sep-container\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#e0dede;\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\" style=\"--awb-text-transform:none;\"><p><strong>Reversal and prevention of obesity in the most vulnerable populations.<\/strong><\/p>\n<p>The <strong>PAS-GRAS<\/strong> project addresses the <strong>main determinants that contribute to the transgenerational risk of obesity in the most vulnerable populations<\/strong>, including children in the prepubertal stage, adolescents and young adults, in order to <strong>reverse and prevent obesity<\/strong> and avoid the emergence of related comorbidities.<\/p>\n<p>To do this, PAS-GRAS determines <strong>lifestyle habits<\/strong> (diet, physical activity\/sedentary activity) and other factors such as mental health, socio-familial and environmental factors, and genetic and metabolic characteristics. The integration of all this data will make possible to <strong>assess the risk on an individual basis <\/strong>and to <strong>design nutritional intervention strategies and therapies to prevent and\/or treat obesity<\/strong>.<\/p>\n<p>PAS-GRAS takes a <strong>transdisciplinary life course approach<\/strong> focused on participatory interventions that will be designed together with overweight and obese people and their families.<\/p>\n<p>Therefore, the objectives of the PAS-GRAS project can be summarized as:<\/p>\n<ul>\n<li>Identify the <strong>factors<\/strong> (biological and environmental) that increase the risk of developing obesity and other complications.<\/li>\n<li>Identify genetic and epigenetic <strong>parameters<\/strong> in early stages of life that predict the possible appearance of obesity.<\/li>\n<li>Identify and study new <strong>blood markers<\/strong> that indicate a communication between the brain and the other organs of the body that ultimately leads to the development of diseases associated with obesity.<\/li>\n<li>Design and validate <strong>nutritional strategies<\/strong> based on natural products that can serve as intervention guides for adults and children.<\/li>\n<li>Generate <strong>digital tools<\/strong> that facilitate commitment and participation in healthy nutritional and physical activity programs, incorporating gender equality and social inclusion.<\/li>\n<\/ul>\n<p>The increasing appearance of obesity in the wake of the world affects not only the global well-being of society, but also generates an unsustainable burden for national health systems. To address the problem, PAS-GRAS envisages a multidisciplinary approach involving biomedicine, social sciences and the humanities to design common strategies and effective interventions.<\/p>\n<p>Eurecat participates in the PAS-GRAS project through its Biotechnology Area units, in charge of the following tasks:<\/p>\n<p><a href=\"https:\/\/eurecat.org\/en\/field-of-knowledge\/nutrition-health\/\">Nutrition and Health Unit<\/a>:<\/p>\n<ul>\n<li>Preclinical study in rodent models for the search for therapeutic approaches that prevent the metabolic programming that leads to obesity in the offspring.<\/li>\n<li>Clinical study of nutritional and lifestyle intervention based on a personalized adaptation of the Mediterranean diet combined with different natural products to reduce the risk factors associated with overweight and obesity.<\/li>\n<li>Co-creation of creative and interactive digital tools, such as comics, videos and physical activity programs, for the empowerment of the vulnerable population in the fight against obesity.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/eurecat.org\/en\/field-of-knowledge\/omic-sciences\/\">Omic Sciences Unit<\/a>:<\/p>\n<ul>\n<li>Study of the epigenomic and metabolic imprints that can stratify obesity and the associated risks.<\/li>\n<li>Analysis of different biochemical parameters (epigenetics, gene expression and metabolism) from clinical and preclinical studies.<\/li>\n<\/ul>\n<p>PAS-GRAS, led by the <a href=\"https:\/\/www.uc.pt\/en\" target=\"_blank\" rel=\"noopener\">University of Coimbra (Portugal)<\/a>, is made up of 16 organizations from eight different countries.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_3 1_3 fusion-one-third fusion-column-last\" style=\"--awb-bg-size:cover;width:30.6666%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"200\" height=\"166\" alt=\"LOGO PAS-GRAS EURECAT\" title=\"Logo PAS-GRAS\" src=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/Logo-PAS-GRAS-200x166.png\" class=\"img-responsive wp-image-142872\" srcset=\"https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/Logo-PAS-GRAS-200x166.png 200w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/Logo-PAS-GRAS-400x333.png 400w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/Logo-PAS-GRAS-600x499.png 600w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/Logo-PAS-GRAS-800x666.png 800w, https:\/\/eurecat.org\/wp-content\/uploads\/2023\/11\/Logo-PAS-GRAS-1200x999.png 1200w\" sizes=\"(max-width: 800px) 100vw, 600px\" \/><\/span><\/div><\/div><div class=\"fusion-title title fusion-title-2 fusion-title-text fusion-title-size-three\" style=\"--awb-margin-top-small:0px;--awb-margin-right-small:0px;--awb-margin-bottom-small:20px;--awb-margin-left-small:0px;\"><h3 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">General details<\/h3><span class=\"awb-title-spacer\"><\/span><div class=\"title-sep-container\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#e0dede;\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-3\" style=\"--awb-text-transform:none;\"><p><strong>Project<\/strong><\/p>\n<p>PAS-GRAS \u2013 De-risking metabolic, environmental and behavioural determinants of obesity in children, adolescents and young adults<\/p>\n<div id=\"gtx-trans\" style=\"position: absolute; left: 121px; top: 77.8099px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-4\" style=\"--awb-text-transform:none;\"><p><strong>Project reference<\/strong><\/p>\n<div class=\"fusion-text fusion-text-4\">\n<p>101080329<\/p>\n<\/div>\n<div id=\"gtx-trans\" style=\"position: absolute; left: 25px; top: 30.6667px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-5\" style=\"--awb-text-transform:none;\"><p><strong>Programme and call for tender<\/strong><\/p>\n<p>Project funded by the European Union\u2019s Horizon Europe programme under the call <em>HORIZON-HLTH-2022-STAYHLTH-01-05-two-stage &#8211; Prevention of obesity throughout the life course <\/em><\/p>\n<div id=\"gtx-trans\" style=\"position: absolute; left: 215px; top: 30.4766px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-6\" style=\"--awb-text-transform:none;\"><p><strong>More information about the project<\/strong><\/p>\n<p><a href=\"https:\/\/cordis.europa.eu\/project\/id\/101080329\" target=\"_blank\" rel=\"noopener\">PAS-GRAS<\/a><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-7\" style=\"--awb-text-transform:none;\"><p><strong>Related ODS<\/strong><\/p>\n<div id=\"gtx-trans\" style=\"position: absolute; left: -38px; top: 30.6667px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n<\/div><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:13px;--awb-content-font-size:14px;--awb-icon-alignment:left;--awb-hover-color:#f9f9f9;--awb-border-color:#cccccc;--awb-background-color:#ffffff;--awb-divider-color:#e0dede;--awb-divider-hover-color:#e0dede;--awb-icon-color:#ffffff;--awb-title-color:#662483;--awb-content-color:#747474;--awb-icon-box-color:#333333;--awb-toggle-hover-accent-color:#642c81;--awb-title-font-family:&quot;Open Sans&quot;;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:13px;--awb-content-font-family:&quot;Open Sans&quot;;--awb-content-font-style:normal;--awb-content-font-weight:400;\"><div class=\"panel-group fusion-toggle-icon-boxed\" id=\"accordion-142864-1\"><div class=\"fusion-panel panel-default panel-15cfe4f362efc24fe fusion-toggle-has-divider\" style=\"--awb-title-color:#662483;--awb-content-color:#747474;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_15cfe4f362efc24fe\"><a aria-expanded=\"false\" aria-controls=\"15cfe4f362efc24fe\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-142864-1\" data-target=\"#15cfe4f362efc24fe\" href=\"#15cfe4f362efc24fe\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">3. Good health and well-being<\/span><\/a><\/h4><\/div><div id=\"15cfe4f362efc24fe\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_15cfe4f362efc24fe\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Prevention of obesity and associated complications<\/p>\n<div id=\"gtx-trans\" style=\"position: absolute; left: 182px; top: 37.8229px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-b419a13653d51b835 fusion-toggle-has-divider\" style=\"--awb-title-color:#662483;--awb-content-color:#747474;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_b419a13653d51b835\"><a aria-expanded=\"false\" aria-controls=\"b419a13653d51b835\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-142864-1\" data-target=\"#b419a13653d51b835\" href=\"#b419a13653d51b835\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">12. Responsible consumption and production<\/span><\/a><\/h4><\/div><div id=\"b419a13653d51b835\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_b419a13653d51b835\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>More sustainable and healthy food<\/p>\n<div id=\"gtx-trans\" style=\"position: absolute; left: 186px; top: -9.51042px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"84\" src=\"https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-400x84.jpg\" alt class=\"img-responsive wp-image-143603\" srcset=\"https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-200x42.jpg 200w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-400x84.jpg 400w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-600x126.jpg 600w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-800x168.jpg 800w, https:\/\/eurecat.org\/wp-content\/uploads\/2022\/06\/EN-Funded-by-the-EU-POS-1200x252.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 600px\" \/><\/span><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":33,"featured_media":142876,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"portfolio_category":[1413,1531,1522],"portfolio_skills":[2483],"portfolio_tags":[],"class_list":["post-142864","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-european-projects","portfolio_category-health-nutrition","portfolio_category-omic-sciences","portfolio_skills-horizon-europe-3"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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