{"id":145461,"date":"2024-01-22T11:47:28","date_gmt":"2024-01-22T10:47:28","guid":{"rendered":"https:\/\/eurecat.org\/?p=145461"},"modified":"2024-01-22T16:09:30","modified_gmt":"2024-01-22T15:09:30","slug":"a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat","status":"publish","type":"post","link":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/","title":{"rendered":"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat"},"content":{"rendered":"

A study by the\u00a0Girona Biomedical Research Institute Dr. Josep Trueta (IDIBGI)<\/a>\u00a0and the\u00a0Eurecat technology centre<\/a>\u00a0reveals\u00a0a link between low levels of histidine in the blood and fatty liver disease. Published in the scientific journal “Cell Reports Medicine<\/em>“, the research suggests new therapeutic opportunities to improve liver health in patients with obesity.<\/p>\n

Non-alcoholic fatty liver disease\u00a0is the most common liver disease worldwide and affects an estimated one in four people. It is characterised by an excessive accumulation of fat in liver cells due to metabolic causes, unrelated to alcohol consumption, and is linked to obesity and diabetes. This research, carried out by both institutions, focused on exploring the relationship between fatty liver disease and histidine, an essential amino acid with important functions in the body. The results show that\u00a0histidine has a significant inverse relationship with fat accumulation in the liver.<\/p>\n

The research team from the\u00a0Nutrition, Eumetabolism and Health\u00a0group at IDIBGI and CIBEROBN reached this conclusion by examining three different groups of people, totalling 651 individuals, either healthy or with varying degrees of fatty liver disease.<\/p>\n

In addition, in the analysis of the\u00a0intestinal microbiota, they identified a group of specific bacteria clearly associated with histidine levels: the more proteobacteria in the intestinal microbiota, the less histidine in the blood. “Proteobacteria have genes involved in histidine degradation and are increased in patients with fatty liver disease,” says\u00a0Dr.\u00a0Jordi Mayneris-Perxachs, IDIBGI senior researcher who led this publication. “This could explain why histidine levels are lower in these patients, and could cause fat accumulation in the liver,” he adds.<\/p>\n

Validation of the results was carried out in collaboration with Eurecat in trials in four different preclinical models, including rodents and the “fruit fly” (Drosophila Melanogaster<\/em>). In all models, histidine supplementation of the diet\u00a0improved the condition of the fatty liver, decreasing the expression of genes involved in fat synthesis and triglyceride levels in the liver.<\/p>\n

“Dietary supplementation with amino acids is known and safe, and the fact that our treatment has worked in different preclinical models makes us think that it can be successfully transferred to people with fatty liver disease,” explains\u00a0Dr. Xavier Escot\u00e9, researcher at the Eurecat Nutrition and Health Unit.<\/p>\n

\"\"

The IDIBGI Nutrition, Eumetabolism and Health<\/a> research team<\/p><\/div>\n

“Currently, fatty liver disease is treated with lifestyle recommendations and some medication, but without a fully effective specific treatment. Therefore, these findings suggest a solid therapeutic target,” says\u00a0Dr.\u00a0Jos\u00e9 Manuel Fern\u00e1ndez-Real, head of the Nutrition, Eumetabolism and Health research group at IDIBGI and CIBEROBN, who is also head of the Endocrinology section at the Josep Trueta Hospital in Girona.<\/p>\n

Therefore, the results of this research may lead to\u00a0explore possible future treatments, such as supplementing the diet with histidine or modifying the microbiota, to improve liver health in patients with obesity. The first authors of the study are Dr.\u00a0Anna Castells-Nobau, researcher at IDIBGI, and Sergio Quesada-V\u00e1zquez, researcher at Eurecat.<\/p>\n

Reference article: Quesada-V\u00e1zquez S, Castells-Nobau A, Latorre J, Oliveras-Ca\u00f1ellas N, Puig-Parnau I, Tejera N, Tobajas Y, Baudin J, Hildebrand F, Beraza N, Burcelin R, Martinez-Gili L, Chilloux J, Dumas ME, Federici M, Hoyles L, Caimari A, Del Bas JM, Escot\u00e9 X, Fern\u00e1ndez-Real JM, Mayneris-Perxachs J. Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity. Cell Rep Med. 2023 Dec 19;4(12):101341. doi: 10.1016\/j.xcrm.2023.101341. PMID: 38118419.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":145441,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[429,743],"tags":[],"class_list":["post-145461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutrition-and-health","category-press-notes-en"],"yoast_head":"\nA link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat - Eurecat<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat - Eurecat\" \/>\n<meta property=\"og:url\" content=\"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/\" \/>\n<meta property=\"og:site_name\" content=\"Eurecat\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-22T10:47:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-22T15:09:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/eurecat.org\/wp-content\/uploads\/2024\/01\/Eurecat_Biotecnologia_800px.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"519\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"EurecatEQZ\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"EurecatEQZ\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/\"},\"author\":{\"name\":\"EurecatEQZ\",\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/#\\\/schema\\\/person\\\/99d4d39712001e7621b6867b27b40bed\"},\"headline\":\"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat\",\"datePublished\":\"2024-01-22T10:47:28+00:00\",\"dateModified\":\"2024-01-22T15:09:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/\"},\"wordCount\":1539,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/eurecat.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/Eurecat_Biotecnologia_800px.jpg\",\"articleSection\":[\"Nutrition and Health\",\"Press Notes\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/\",\"url\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/\",\"name\":\"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat - Eurecat\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/eurecat.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/Eurecat_Biotecnologia_800px.jpg\",\"datePublished\":\"2024-01-22T10:47:28+00:00\",\"dateModified\":\"2024-01-22T15:09:30+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/#\\\/schema\\\/person\\\/99d4d39712001e7621b6867b27b40bed\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#primaryimage\",\"url\":\"https:\\\/\\\/eurecat.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/Eurecat_Biotecnologia_800px.jpg\",\"contentUrl\":\"https:\\\/\\\/eurecat.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/Eurecat_Biotecnologia_800px.jpg\",\"width\":800,\"height\":519},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Inici\",\"item\":\"https:\\\/\\\/eurecat.org\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/eurecat.org\\\/en\\\/\",\"name\":\"Eurecat\",\"description\":\"Otro sitio realizado con WordPress\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/eurecat.org\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/eurecat.org\\\/en\\\/#\\\/schema\\\/person\\\/99d4d39712001e7621b6867b27b40bed\",\"name\":\"EurecatEQZ\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6deb26ca61bcc34263c59cc62bb8b08ff90b67af7f99943babf5d86396845993?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6deb26ca61bcc34263c59cc62bb8b08ff90b67af7f99943babf5d86396845993?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6deb26ca61bcc34263c59cc62bb8b08ff90b67af7f99943babf5d86396845993?s=96&d=mm&r=g\",\"caption\":\"EurecatEQZ\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat - Eurecat","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/","og_locale":"en_US","og_type":"article","og_title":"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat - Eurecat","og_url":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/","og_site_name":"Eurecat","article_published_time":"2024-01-22T10:47:28+00:00","article_modified_time":"2024-01-22T15:09:30+00:00","og_image":[{"width":800,"height":519,"url":"https:\/\/eurecat.org\/wp-content\/uploads\/2024\/01\/Eurecat_Biotecnologia_800px.jpg","type":"image\/jpeg"}],"author":"EurecatEQZ","twitter_card":"summary_large_image","twitter_misc":{"Written by":"EurecatEQZ","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#article","isPartOf":{"@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/"},"author":{"name":"EurecatEQZ","@id":"https:\/\/eurecat.org\/en\/#\/schema\/person\/99d4d39712001e7621b6867b27b40bed"},"headline":"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat","datePublished":"2024-01-22T10:47:28+00:00","dateModified":"2024-01-22T15:09:30+00:00","mainEntityOfPage":{"@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/"},"wordCount":1539,"commentCount":0,"image":{"@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#primaryimage"},"thumbnailUrl":"https:\/\/eurecat.org\/wp-content\/uploads\/2024\/01\/Eurecat_Biotecnologia_800px.jpg","articleSection":["Nutrition and Health","Press Notes"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/","url":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/","name":"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat - Eurecat","isPartOf":{"@id":"https:\/\/eurecat.org\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#primaryimage"},"image":{"@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#primaryimage"},"thumbnailUrl":"https:\/\/eurecat.org\/wp-content\/uploads\/2024\/01\/Eurecat_Biotecnologia_800px.jpg","datePublished":"2024-01-22T10:47:28+00:00","dateModified":"2024-01-22T15:09:30+00:00","author":{"@id":"https:\/\/eurecat.org\/en\/#\/schema\/person\/99d4d39712001e7621b6867b27b40bed"},"breadcrumb":{"@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#primaryimage","url":"https:\/\/eurecat.org\/wp-content\/uploads\/2024\/01\/Eurecat_Biotecnologia_800px.jpg","contentUrl":"https:\/\/eurecat.org\/wp-content\/uploads\/2024\/01\/Eurecat_Biotecnologia_800px.jpg","width":800,"height":519},{"@type":"BreadcrumbList","@id":"https:\/\/eurecat.org\/en\/a-link-between-histidine-and-fatty-liver-disease-discovered-in-a-study-by-idibgi-and-eurecat\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Inici","item":"https:\/\/eurecat.org\/en\/"},{"@type":"ListItem","position":2,"name":"A link between histidine and fatty liver disease discovered in a study by IDIBGI and Eurecat"}]},{"@type":"WebSite","@id":"https:\/\/eurecat.org\/en\/#website","url":"https:\/\/eurecat.org\/en\/","name":"Eurecat","description":"Otro sitio realizado con WordPress","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/eurecat.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/eurecat.org\/en\/#\/schema\/person\/99d4d39712001e7621b6867b27b40bed","name":"EurecatEQZ","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/6deb26ca61bcc34263c59cc62bb8b08ff90b67af7f99943babf5d86396845993?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6deb26ca61bcc34263c59cc62bb8b08ff90b67af7f99943babf5d86396845993?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6deb26ca61bcc34263c59cc62bb8b08ff90b67af7f99943babf5d86396845993?s=96&d=mm&r=g","caption":"EurecatEQZ"}}]}},"_links":{"self":[{"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/posts\/145461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/comments?post=145461"}],"version-history":[{"count":1,"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/posts\/145461\/revisions"}],"predecessor-version":[{"id":145471,"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/posts\/145461\/revisions\/145471"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/media\/145441"}],"wp:attachment":[{"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/media?parent=145461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/categories?post=145461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eurecat.org\/en\/wp-json\/wp\/v2\/tags?post=145461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}