{"id":189929,"date":"2025-08-28T12:19:30","date_gmt":"2025-08-28T10:19:30","guid":{"rendered":"https:\/\/eurecat.org\/?p=189929"},"modified":"2025-11-03T16:07:46","modified_gmt":"2025-11-03T15:07:46","slug":"eurecat-demonstrates-photoprotective-and-anti-inflammatory-potential-of-compounds-from-agricultural-waste-to-improve-skin-health","status":"publish","type":"post","link":"https:\/\/eurecat.org\/en\/eurecat-demonstrates-photoprotective-and-anti-inflammatory-potential-of-compounds-from-agricultural-waste-to-improve-skin-health\/","title":{"rendered":"Eurecat demonstrates photoprotective and anti-inflammatory potential of compounds from agricultural waste to improve skin health"},"content":{"rendered":"

The Eurecat<\/a> technology centre has demonstrated the photoprotective and anti-inflammatory potential of polyphenol-rich extracts from agricultural by-products such as chicory leaves, red onion skins, vine prunings and olive prunings, proving their effectiveness in three-dimensional in vitro<\/em> models equivalent to human skin exposed to UV-B radiation in a paper<\/a> recently published in the Journal of Agriculture and Food Research<\/em>.<\/p>\n

As part of the European Phenolexa project, which targets revalorisation of agricultural by-products, the effects of four polyphenolic extracts from agricultural waste on various skin health parameters, including collagen metabolism, inflammation and prevention of structural damage to cells when exposed to ultraviolet rays, have been analysed.<\/p>\n

All the extracts \u201csignificantly reduced the presence of burnt skin cells by between 48 and 68 per cent, two of them exerted an exciting modulation of extracellular matrix components, and one of these also showed an anti-inflammatory effect,\u201d comments Joan Teichenn\u00e9, a researcher in Eurecat\u2019s Nutrition and Health Unit. Specifically, \u201cred onion skin and vine pruning extracts increased the expression of genes related to collagen synthesis, while vine pruning extract also demonstrated the ability to significantly reduce the gene expression of a key protein in inflammatory processes,\u201d adds Dr Roger Marin\u00e9, also a researcher in Eurecat\u2019s Nutrition and Health Unit.<\/p>\n

The research tapped advanced extraction technologies with green, sustainable and environmentally-friendly solvents. The extracts were also tested in advanced in vitro<\/em> 3D human skin models, an innovative and physiologically relevant system which allows for evaluations more closely aligned with human conditions while lessening reliance on animal testing in research.<\/p>\n

This \u201cis the first study to combine a green extraction technique, subcritical water extraction, with a three-dimensional model of human skin mimicking its layers,\u201d explains Dr Xavier Escot\u00e9, a collaborator at Eurecat\u2019s Nutrition and Health Unit and lecturer at Rovira i Virgili University. \u201cThis is a step forward in developing sustainable cosmetic bioactives with potential applications in photoprotection, anti-ageing and revalorising agri-food waste through the circular economy.\u201d<\/p>\n

\u201cThe research paves the way for potential applications of residual biomass from agricultural processes for sustainable reuse in sectors such as cosmetics and food to improve people\u2019s health and well-being,\u201d comments Sara G\u00f3mez, director of Eurecat\u2019s Nutrition and Health Unit.<\/p>\n

\u201cThis study demonstrates Eurecat\u2019s commitment to capacity building and using alternatives to animal testing, evolving from simple single-cell systems to increasingly complex models which more accurately reproduce the behaviour of human organs,\u201d adds Antoni Caimari, Director of Eurecat\u2019s Biotechnology Area. \u201cThis enables us to stay at the forefront in nutrition and health, offering robust alternatives to the use of animals to evaluate the functionality of ingredients, nutraceuticals and other bioactive compounds.\u201d<\/p>\n

The Phenolexa project, funded by the European Union\u2019s Horizon 2020 programme, is a European initiative based on processing various types of agricultural waste to produce a suite of novel functional polyphenolic bioactives with beneficial properties for human health. Eurecat\u2019s Nutrition and Health Unit has also demonstrated the antiviral potential of some of these extracts in another scientific paper<\/a> just published in the journal Molecules<\/em>.<\/p>\n

The project consortium, led by CIVITTA<\/a>, is made up of 12 partners from several European countries: Novatica<\/a> Technologies, the Italian National Research Council (CNR)<\/a>, the CARTIF Technology Centre<\/a>, Celabor<\/a>, the Nicolaus <\/a>Copernicus University of Torun (Poland), the University of <\/a>Loughborough in the United Kingdom, Bionigree<\/a>, the EPC-Project Corporation <\/a>Climate association, the Regional Chamber of Agriculture of <\/a>Provence Alpes C\u00f4te d\u2019Azur and Carinsa<\/a>.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":187917,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2295,429,743],"tags":[],"class_list":["post-189929","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-food","category-nutrition-and-health","category-press-notes-en"],"yoast_head":"\nEurecat demonstrates photoprotective and anti-inflammatory potential of compounds from agricultural waste to improve skin health - 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